A pharmacokinetic study comparing diclofenac 1% gel to oral diclofenac found significantly less systemic absorption with topical diclofenac.¹⁰When compared to a 150 mg daily dose of oral diclofenac, the Area Under the Curve (AUC) of a 48 g daily dose and 28 g daily dose of 1% diclofenac gel was 5- and 17-fold less, respectively. One of the two topical vs. oral diclofenac studies was a 12-week double-blind, double-dummy study comparing topical diclofenac solution (1.5% diclofenac sodium in 45.5% dimethyl sulfoxide [DMSO]) with oral diclofenac capsules 50 mg three times daily (the maximum daily dose) in patients with symptomatic primary knee OA (per protocol N = 492) []. Sodium reduces the concentration of electrolytes in the blood and triggers one’s thirst mechanism. Kidneys retain water to balance the electrolyte concentration in your body. It also boosts the Diclofenac Side Effects. Common side effects include diarrhea, constipation, gas, bloating, headache, dizziness and ringing in the ears. These side effects may be combatted by drinking plenty of water and other hydrating fluids. If your side effects do not go away, appear to be severe or are inhibiting your ability to function, talk to your Diclofenac (Topical Application Route) Merative, Micromedex. Diclofenac is used to treat pain and other symptoms of arthritis of the joints (eg, osteoarthritis), such as inflammation, swelling, stiffness, and joint pain. However, this medicine does not cure osteoarthritis and will help you only as long as you continue to use it. AquariusAnneCA 21 Sep 2012. My direct answer to your question is to not take any medication at all for your problem! A strained groin muscle will heal itself with the proper treatment without medication. Physical therapy is the answer and also water therapy is a good comfort. Icing it and lying down helps. U3Xjrv3.

how fast does diclofenac sodium work